What question did this study set out to answer?

This research aims to determine if symptoms of depression and anxiety can predict disability progression in individuals with progressive MS.

March 7, 2026Open Access

Symptoms of depression and anxiety are early predictors of multi-domain disability progression in progressive MS

Key Points

This research aims to determine if symptoms of depression and anxiety can predict disability progression in individuals with progressive MS.
Utilized HADS scores to assess depressive and anxiety symptoms.
Monitored disability progression over time in patients with progressive MS.
Analyzed the relationship between symptom scores and changes in disability.
Higher HADS scores, especially for depression, strongly predicted disability progression.
Patient-reported outcomes showed significant prognostic value for disease worsening.

Abstract

Higher HADS scores, particularly depressive symptoms, predicted disability progression. These findings indicate prognostic value of patient-reported outcomes in predicting disease worsening and their potential use in guiding personalised treatment in progressive MS.

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