Nattokinase-Related Aggravation of Histamine Intolerance in Diamine Oxidase Deficiency: A Rare Clinical Observation

Key Points

• The aim is to explore the relationship between nattokinase and histamine intolerance in patients with diamine oxidase deficiency.
• Clinical observation of patients with diagnosed diamine oxidase deficiency.
• Monitoring of histamine levels in response to nattokinase treatment.
• Nattokinase treatment was associated with increased symptoms of histamine intolerance.
• Histamine levels were significantly elevated in patients after becoming symptomatic.