Does eplerenone suppress collagen turnover changes in patients with congestive heart failure and left ventricular systolic dysfunction after acute myocardial infarction?
High levels of type I collagen telopeptide and BNP predict higher event rates post-AMI, and eplerenone can suppress these adverse collagen turnover changes.
Changes in biomarkers of collagen synthesis and degradation suggest that extracellular matrix remodeling is an active process in patients with congestive heart failure and left ventricular systolic dysfunction after acute myocardial infarction. High type I collagen telopeptide and high brain natriuretic peptide serum levels are associated with the highest event rate. Eplerenone suppresses post-acute myocardial infarction collagen turnover changes.
Iraqi et al. (2009) studied this question.