Does eplerenone suppress collagen turnover changes in patients with congestive heart failure and left ventricular systolic dysfunction after acute myocardial infarction?
Patients with congestive heart failure and left ventricular systolic dysfunction after acute myocardial infarction
Eplerenone
Collagen turnover changes and event ratesurrogate
High levels of type I collagen telopeptide and BNP predict higher event rates post-AMI, and eplerenone can suppress these adverse collagen turnover changes.
Changes in biomarkers of collagen synthesis and degradation suggest that extracellular matrix remodeling is an active process in patients with congestive heart failure and left ventricular systolic dysfunction after acute myocardial infarction. High type I collagen telopeptide and high brain natriuretic peptide serum levels are associated with the highest event rate. Eplerenone suppresses post-acute myocardial infarction collagen turnover changes.
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Iraqi et al. (Tue,) studied this question.
synapsesocial.com/papers/69af0aefe03f6d79082a8c6c — DOI: https://doi.org/10.1161/circulationaha.108.809194
Wafae Iraqi
Janssen (France)
Patrick Rossignol
Heart Failure & Transplant
Michaël Angioı̈
Interventional Cardiology
Circulation
University of Michigan
Pfizer (United States)
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