Key result
Collagen type I and III turnover biomarkers demonstrate diagnostic and prognostic utility for noninvasive myocardial fibrosis assessment.
Why the study?
Myocardial fibrosis contributes to morbidity and mortality in heart disease, but detection typically relies on cardiac magnetic resonance or endomyocardial biopsy, making collagen turnover biomarkers an important noninvasive alternative.
Does the assessment of collagen turnover biomarkers provide diagnostic and prognostic utility for myocardial fibrosis in patients with heart disease?
Does the assessment of collagen turnover biomarkers provide diagnostic and prognostic utility for myocardial fibrosis in patients with heart disease?
Collagen turnover biomarkers offer a promising noninvasive alternative to cardiac magnetic resonance or endomyocardial biopsy for assessing myocardial fibrosis.
May support noninvasive fibrosis assessment in heart disease; leaves open clinical adoption pending prospective validation.
The pro-fibrotic milieu, as the result of the extracellular matrix remodeling, is a central feature in the pathophysiology of heart disease and contributes to its high morbidity and mortality. Fibrosis is a recognized risk factor for development of heart failure and arrythmias and is usually detected by cardiac magnetic resonance or endomyocardial biopsy. Collagen type I and type III are major components of the collagen network, and the assessment of their derived biomarkers could serve as estimate of the myocardial fibrotic content. This review summarizes data from numerous studies in which these biomarkers have proven their diagnostic and prognostic utility, setting the stage for further randomized clinical trials that might translate into early implementation of antifibrotic therapies.
No takes yet. Share an insight, caveat, or question.
Ureche et al. (2020) conducted a review in Myocardial fibrosis. Collagen turnover biomarkers (type I and type III) was evaluated. Collagen type I and type III turnover biomarkers demonstrate diagnostic and prognostic utility for the noninvasive assessment of myocardial fibrosis.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: