Why the study?
Do serum collagen biomarkers (PINP, PIIINP, PICP, ICTP) have prognostic or diagnostic utility in cardiac disease?
Do serum collagen biomarkers (PINP, PIIINP, PICP, ICTP) have prognostic or diagnostic utility in cardiac disease?
Serum collagen biomarkers (PINP, PIIINP, PICP, ICTP) are under active investigation as prognostic and diagnostic tools for cardiac fibrosis in heart failure, though they have limitations.
Serum collagen biomarkers have limited utility for cardiac fibrosis assessment; leaves open their prognostic value pending prospective validation.
Increased myocardial collagen accumulation is present in almost every cardiac disease and plays an important role in the reduced heart function. N-terminal and C-terminal propeptides of collagen type I and III, the two major collagen types in the heart, can be assayed in serum.These propeptides (PINP, PIIINP, PICP, ICTP) reflect collagen synthesis and degradation. The use of these serum collagen biomarkers as prognostic or diagnostic tools is an area of active investigation. In this review article these studies will be discussed as well as the limitations of these serum biomarkers as indicators of cardiac fibrosis.
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Lijnen et al. (2012) studied this question.
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