May 7, 2014Journal of Cardiovascular Medicine

Biomarkers of collagen type I metabolism are related to B-type natriuretic peptide, left ventricular size, and diastolic function in heart failure

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Population

132 patients aged 60 years or older with systolic heart failure, mean age 75 years.

Design

Cross-sectional

Authors

JLJohan LöfsjögårdDanderyds sjukhus TKThomas KahanPreventive Cardiology JDJavier Dı́ezUniversidad Complutense de Madrid

Discussion

Member takes

Implication

Should not yet change practice in systolic HF; leaves open collagen turnover as a remodeling biomarker.

Structured PICO

Population

132 patients (57 women and 75 men) aged 60 years or older with systolic heart failure (NYHA class II-IV and ejection fraction ≤ 45%), mean age 75 years.

Outcome

Associations between biomarkers of collagen type I synthesis (PICP) and degradation (CITP) and B-type natriuretic peptide (BNP), left ventricular size, and diastolic function.surrogate

Biomarkers of collagen type I synthesis and degradation are independently associated with BNP levels, left ventricular size, and diastolic function in patients with systolic heart failure.

Cite This Study

Löfsjögård et al. (2014) studied this question.

synapsesocial.com/papers/6a9111eff69e67dea4361b2b https://doi.org/10.2459/01.jcm.0000435617.86180.0b

Topics

HFrEF treatment Heart failure

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Biomarkers of collagen type I metabolism are related to B-type natriuretic peptide, left ventricular size, and diastolic function in heart failure

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Topics

Biomarkers of collagen type I metabolism are related to B-type natriuretic peptide, left ventricular size, and diastolic function in heart failure

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Topics

Also Consider