Left atrial volume, left atrial appendage orifice size, and depth correlated strongly with thrombus presence or stroke history in computational models of patients with atrial fibrillation.
Observational (n=40)
CFD-based hemodynamic and morphometric parameters, such as LA volume and LAA orifice size, correlate strongly with thrombus presence or stroke history in AF patients, potentially complementing clinical risk scores.
PURPOSE: Stroke is a leading cause of death worldwide, with atrial fibrillation (AF) contributing to up to a third of ischemic strokes. Current clinical risk scores, like the CHA METHODS: We analyzed 40 patient-specific LA models reconstructed from computed tomography, incorporating a physiologically realistic atrial wall motion derived from an AF motion model. High-fidelity CFD simulations were performed under pathological conditions to compute hemodynamic and morphometric parameters, which were then statistically correlated with thrombus presence or stroke history. RESULTS: Univariate logistic analysis showed that LA volume, left atrial appendage (LAA) orifice size, and LAA depth correlated strongly with thrombus presence or stroke history (Pseudo CONCLUSION: These results demonstrate that CFD-based and morphometric parameters can complement the CHA
Kjeldsberg et al. (Fri,) conducted a observational in Atrial fibrillation (n=40). Hemodynamic and morphometric parameters (LA volume, LAA orifice size, LAA depth) was evaluated on Thrombus presence or stroke history. Left atrial volume, left atrial appendage orifice size, and depth correlated strongly with thrombus presence or stroke history in computational models of patients with atrial fibrillation.
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