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March 10, 2026The Laryngoscope0 citationsOpen Access

Systemic Immunosuppression as Adjunct Therapy for ANCA-Negative Subglottic Stenosis

Systemic Immunosuppression to Reduce Surgical Intervention in ANCA ‐Negative Subglottic Stenosis

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Authors

EBEA B BensiSMStephen P. McAdooRKRomana Kuchai

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Overview

Retrospective study evaluates systemic immunosuppression to improve outcomes in ANCA-negative subglottic stenosis, suggesting better disease management.

Key Points

  • Evaluate the effectiveness of systemic immunosuppression as an adjunctive treatment for patients with idiopathic subglottic stenosis (iSGS) and granulomatosis with polyangiitis (GPA) undergoing surgical management.
  • Conducted a retrospective study at a tertiary airway center
  • Categorized patients into idiopathic SGS and GPA-SGS
  • Classified aggressive iSGS patients as atypical-SGS
  • Administered systemic immunosuppression in GPA-SGS and atypical-SGS cohorts alongside surgery
  • Assessed disease activity through inter-dilation interval (IDI) before and after treatment.
  • Included 60 patients: 33 with iSGS, 20 with GPA-SGS, and 7 with atypical SGS
  • Atypical SGS showed significant increase in IDI from 7.6 months to 27.8 months post-treatment (p=0.0496)
  • GPA-SGS demonstrated IDI increase from 8.9 months to 26.0 months post-treatment (p=0.0027)
  • No significant adverse events were observed.

Cite This Study

Bensi et al. (2026) studied this question.

synapsesocial.com/papers/69af944f70916d39fea4b4fbhttps://doi.org/10.1002/lary.70466
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