Retrospective study evaluates systemic immunosuppression to improve outcomes in ANCA-negative subglottic stenosis, suggesting better disease management.
Key Points
Evaluate the effectiveness of systemic immunosuppression as an adjunctive treatment for patients with idiopathic subglottic stenosis (iSGS) and granulomatosis with polyangiitis (GPA) undergoing surgical management.
Conducted a retrospective study at a tertiary airway center
Categorized patients into idiopathic SGS and GPA-SGS
Classified aggressive iSGS patients as atypical-SGS
Administered systemic immunosuppression in GPA-SGS and atypical-SGS cohorts alongside surgery
Assessed disease activity through inter-dilation interval (IDI) before and after treatment.
Included 60 patients: 33 with iSGS, 20 with GPA-SGS, and 7 with atypical SGS
Atypical SGS showed significant increase in IDI from 7.6 months to 27.8 months post-treatment (p=0.0496)
GPA-SGS demonstrated IDI increase from 8.9 months to 26.0 months post-treatment (p=0.0027)