Prevalence of Synchronous and Metachronous Malignancy in Sinonasal Inverted Papilloma: Meta‐Analysis

Objective Sinonasal inverted papilloma (IP) is a benign epithelial neoplasm with a propensity for malignant transformation. Reported rates of synchronous or metachronous carcinoma vary widely. Our aim was to determine the rates of both synchronous and metachronous malignancy in patients with IP. Data Sources Embase, MEDLINE, Web of Science, and Cochrane Library were searched from 2005 until June 2026. Review Methods We conducted a systematic review and meta‐analysis in accordance with PRISMA guidelines. Prevalences were pooled using a random‐effects model. Results A total of 68 studies ( n = 7412 patients) were identified. The pooled prevalence of overall malignancy was 5.6% (95% CI: 4.5–6.8), comprising synchronous malignancy in 4.3% (95% CI: 3.4–5.3), and metachronous malignancy in 1.3% (95% CI: 0.8–2.0). The pooled recurrence rate was 17.5% (95% CI: 15.0–20.2). Conclusions These weighted, IP‐specific estimates place the prevalence of malignancy in inverted papilloma below the figures most often cited in the literature. These findings provide a methodologically robust benchmark for patient counseling and postoperative surveillance.