What question did this study set out to answer?

This research aims to address the challenges in identifying rare ABO subgroups in deceased organ donors.

March 10, 2026Transfusion0 citations

Deceased donor ABO discrepancy due to a rare AwB subgroup: Implications for organ allocation

SDSara O. DionneEurofins (Germany)KSKelsey C. SmithIowa State University LSLuis SantiagoEurofins (Germany)

Key Points

This research aims to address the challenges in identifying rare ABO subgroups in deceased organ donors.
Case analysis of ABO discrepancies in deceased donors.
Integration of molecular genotyping with traditional serologic testing.
Assessment of current ABO determination workflows and gaps.
Identification of a rare weak ABO subgroup affecting organ allocation.
Evidence that molecular genotyping can resolve ABO discrepancies.
Highlighting the need for standardized inter-laboratory data sharing.

Abstract

This case highlights the vulnerability of routine serologic testing to misclassification of rare weak ABO subgroups. Integration of molecular genotyping with serologic testing can provide resolution of ABO discrepancies and enhance transplant safety. This case demonstrates a policy-relevant gap in current ABO determination workflows for deceased donors. Lack of standardized inter-laboratory data sharing and limited access to rapid molecular testing may unnecessarily restrict organ utilization.

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