What question did this study set out to answer?

To investigate how Cx3cr1 haploinsufficiency affects ALS and Alzheimer’s risk genes in a tauopathy model.

March 10, 2026Molecular Neurodegeneration Advances0 citationsOpen Access

Female-specific Cx3cr1-driven regulation of ALS and Alzheimer’s risk genes in tauopathy

ASAri SudwartsUniversity of South Florida GTGopal ThinakaranUniversity of South Florida

Key Points

To investigate how Cx3cr1 haploinsufficiency affects ALS and Alzheimer’s risk genes in a tauopathy model.
Utilized P301S (PS19) transgenic model of tau pathology.
Induced haploinsufficiency of Cx3cr1.
Analyzed transcriptional changes in genetic risk factors for ALS and Alzheimer’s.
Notable transcriptional changes observed in ALS and Alzheimer’s risk genes.
Several risk genes showed co-expression, indicating possible gene-gene interactions.
Findings suggest that Cx3cr1 has a sex-specific role in regulating these risk genes.

Abstract

By introducing haploinsufficiency of Cx3cr1 in the P301S (PS19) transgenic model of tau pathology, we report remarkable transcriptional changes, including crucial amyotrophic lateral sclerosis and Alzheimer’s disease risk genes, several of which showed co-expression, suggesting gene–gene interactions among these genetic risk factors.

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