What question did this study set out to answer?

To investigate how C1q interaction influences thrombin generation and related signaling pathways in vascular cells.

March 10, 2026Immunity Inflammation and Disease0 citationsOpen Access

Thrombin Generation Induced by Complement Component C1q Interaction With the Receptor for the Globular Head of C1q on Adventitial Fibroblasts and Vascular Smooth Muscle Cells

CFChristopher Thor FredaStony Brook University WYWei YinNew Jersey Institute of Technology BGBerhane GhebrehiwetStony Brook University

Key Points

To investigate how C1q interaction influences thrombin generation and related signaling pathways in vascular cells.
Measured TF expression in response to C1q exposure
Analyzed activation of the extrinsic coagulation cascade
Assessed changes in Akt/p-Akt levels
C1q exposure significantly increased TF expression
Elevated zymogen formation within the extrinsic coagulation cascade
Altered levels of Akt and p-Akt were observed

Abstract

Our results indicate that TF expression in response to C1q exposure accelerates zymogen formation within the extrinsic coagulation cascade and alters Akt/p-Akt expression. Overall, these findings highlight a significant connection between altered innate inflammation and heightened thrombin generation.

问 AI

Bookmark

View Full Paper

Cite This Study

Freda et al. (Sun,) studied this question.

synapsesocial.com/papers/69af954870916d39fea4cbe3 https://doi.org/https://doi.org/10.1002/iid3.70374

问 AI

Bookmark

View Full Paper