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Synapse
March 12, 20260 citationsOpen Access

A Meta-analysis to Identify Common Key Genes Across Ageing, Alzheimer's and Parkinson's Diseases.

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MCMona ChaurasiyaSCSai Nikhith CholletiGPGauri Prasad

Key Points

  • The research aims to identify shared genes across ageing and neurodegenerative diseases such as Alzheimer's and Parkinson's.
  • Conducted a meta-analysis integrating transcriptomic data, network analysis, and miRNA studies.
  • Focused on identifying common molecular pathways among the diseases.
  • Analyzed physiological ageing alongside pathological neurodegeneration.
  • Identified a neurodegenerative molecular core shared across the three conditions.
  • Revealed several key regulatory nodes that could serve as targets for new therapies.
  • Demonstrated systems-level convergence in gene expression related to ageing and disease.

Abstract

This study defines a shared neurodegenerative molecular core that bridges physiological AG with pathological neurodegeneration. The integration of transcriptomic, network, and miRNA analyses reveals systems-level convergence and identifies key regulatory nodes as attractive targets for cross-disease therapeutic strategies.

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Cite This Study

Chaurasiya et al. (2026) studied this question.

synapsesocial.com/papers/69b2573196eeacc4fcec5d8bhttps://doi.org/10.1177/09727531261420619
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Comparative Multi-Omics Analysis Identifies Shared Transcriptomic Signatures and Therapeutic Targets in Alzheimer’s, Parkinson’s, and Huntington’s Diseases2025
  2. 2Comparative Multi-Omics Analysis Identifies Shared Transcriptomic Signatures and Therapeutic Targets in Alzheimer’s, Parkinson’s, and Huntington’s Diseases2025 · 4 citations
  3. 3Using a Systems Biology Approach To Reveal a Common Molecular Signature Across Neurodegenerative Diseases2024
  4. 4Exploring Gene Expression Patterns in Alzheimer’s Disease Using a Human Microarray Data Meta-Analysis2026 · 1 citations
  5. 5Shared molecular mechanisms in aging and neurodegenerative diseases: from mechanistic insights to therapeutic strategies2026 · 2 citations