What does this research mean for the field?

Neuroinflammation disrupts the PVM/Ms-VEGF/PEDF-junctional protein axis, leading to blood-labyrinth barrier instability and subsequent repair processes in the cochlea. Novelty: ClaimNovelty.NOVEL_FINDING. Consensus alignment: ConsensusAlignment.NEUTRAL.

What question did this study set out to answer?

To characterize proteomic changes related to cochlear vascular injury and the associated repair processes involving PVM/Ms.

March 12, 2026Acta Oto-Laryngologica0 citations

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Proteomic characterization of cochlea vascular injury and PVM/Ms-associated repair using iTRAQ and PRM approaches

QWQin WangChinese PLA General Hospital TZTong ZhangRutgers, The State University of New Jersey CTChaoying TangBeijing Chao-Yang Hospital

Key Points

To characterize proteomic changes related to cochlear vascular injury and the associated repair processes involving PVM/Ms.
Utilized iTRAQ and PRM techniques for proteomic analysis
Focused on the disruption of the PVM/Ms-VEGF/PEDF-junctional protein axis
Investigated time-dependent responses to NE
Identified disruption in PVM/Ms-VEGF/PEDF junctional protein axis
Demonstrated instability in the blood-labyrinth barrier (BLB)
Outlined potential repair pathways linked to PVM/Ms activity

Abstract

NE triggers a coordinated, time-dependent disruption of the PVM/Ms-VEGF/PEDF-junctional protein axis, driving BLB instability and repair.

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Proteomic characterization of cochlea vascular injury and PVM/Ms-associated repair using iTRAQ and PRM approaches

Key Points

Abstract

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