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March 12, 2026ESMO rare cancers.0 citationsOpen Access

95P Single-cell transcriptomics of synovial sarcoma reveals four molecular subtypes featuring a non-canonical subtype with downregulated SS18::SSX activity

ATArtem L. ToropovEKElena KopantsevaAIA. Ikonnikov

Key Points

  • This research aims to categorize synovial sarcoma into distinct molecular subtypes using single-cell transcriptomics.
  • Conducted single-cell transcriptomic analysis of synovial sarcoma samples
  • Identified and characterized four distinct molecular subtypes
  • Investigated the activity of ss18:ssx in each subtype
  • Identified four molecular subtypes in synovial sarcoma
  • Discovered a non-canonical subtype with significantly downregulated ss18:ssx activity
  • Found correlations between delay in diagnosis and tumor characteristics, including size and stage

Abstract

delay presented with Stage III/IV, compared with 45% in the <6-month group.Longer delays correlated positively with larger tumor size.15% were initially misdiagnosed as benign, resulting in 12% unplanned excisions.Conclusions: Extensive diagnostic delay-beginning at the first medical encounter-is strongly associated with increased tumor burden, advanced stage, and inappropriate early interventions.These findings highlight the need for improved symptom recognition across specialties, streamlined referral pathways to sarcoma centers, and public awareness regarding persistent or enlarging soft-tissue masses to reduce late presentations in low-resource systems.

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Cite This Study

Toropov et al. (2026) studied this question.

synapsesocial.com/papers/69b2579096eeacc4fcec6553https://doi.org/10.1016/j.esmorc.2026.100301
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Synovial sarcoma. A Scandinavian Sarcoma Group project2001 · 35 citations
  2. 2Diagnostic challenges in synovial sarcoma: a case report2026
  3. 3Molecular Profiling Defines Three Subtypes of Synovial Sarcoma2024 · 9 citations
  4. 4Evaluating the clinico-pathological features including the immunohistochemical and molecular landscape of synovial sarcoma cases from a tertiary care cancer referral centre in India2025
  5. 5Molecular Profiling of SYT-SSX Fusion Transcripts for Enhanced Diagnosis of Synovial Sarcomas2025