Ehlers-Danlos syndrome is a genetic disorder that affects connective tissue and causes abnormal collagen synthesis, which affects the skin, ligaments, joints, and blood vessels. Several studies corroborate that female patient with this syndrome shows various gynecological symptoms and conditions such as dyspareunia, vulvodynia, dysmenorrhea, and endometriosis. Therefore, the objective of this systematic review and meta-analysis was to determine the prevalence of dyspareunia, dysmenorrhea, and endometriosis in patients diagnosed with Ehlers-Danlos syndrome. This systematic review included seven studies that analyzed patients with gynecological complications and diagnosed with Ehlers-Danlos syndrome. Of these, six were used to measure the combined prevalence of endometriosis and dyspareunia, and only four were used to determine the proportion of dysmenorrhea among patients. In this way, we found a combined prevalence of 78% (95% CI: 65 - 91) with dysmenorrhea, 53% (95% CI: 38 - 68) of patients with dyspareunia and 14% (95% CI: 6 - 23) with endometriosis. We can conclude that dysmenorrhea is the most prevalent gynecological symptom in patients with Ehlers-Danlos syndrome, followed by dyspareunia. Endometriosis is a condition that occurs in 14% of these patients, so its evaluation should be considered in patients diagnosed with Ehlers-Danlos.
C. et al. (Thu,) studied this question.