Structure–function mapping of host defense peptide mimics reveals strategies for antibacterial activity and eradication of mature bacterial biofilms

Key Points

• This research aims to understand how host defense peptide mimics can effectively target and eliminate bacterial biofilms.
• Synthesis of biodegradable host defense peptide mimics using greener epoxide-α-amino acid NCA methods.
• Assessment of antibacterial activity against mature bacterial biofilms.
• Evaluation of material and energy efficiency in biofilm eradication.
• Biodegradable peptide mimics effectively clear mature bacterial biofilms.
• Synthesis methods reduced material and energy use compared to traditional approaches.