What question did this study set out to answer?

To investigate the occurrence of granuloma annulare on irradiated skin in breast cancer patients.

March 12, 2026JEADV Clinical Practice0 citationsOpen Access

Post‐Radiation Granuloma Annulare: A Series of Three Cases

LSLéa ScheidHôpitaux Universitaires de Strasbourg MMM. MitcovHôpitaux Universitaires de Strasbourg DLD. LipskerHôpitaux Universitaires de Strasbourg

Key Points

To investigate the occurrence of granuloma annulare on irradiated skin in breast cancer patients.
Reported cases of three women in their seventies with biopsy-confirmed granuloma annulare.
Lesion timing noted relative to radiation therapy: onset during and months post-treatment.
Observed spread of lesions in two cases after initial appearance.
All cases confirmed granuloma annulare on irradiated skin.
One lesion emerged immediately with others developing 4 and 15 months post-radiation.
Two patients experienced lesion spread to other body areas.

Abstract

ABSTRACT We report typical cases of biopsy confirmed granuloma annulare occurring on irradiated skin in the context of breast cancer in three women in their seventies. The lesions appeared immediately after start of irradiation in one patient, 4 and 15 months after the end of radiation treatment in the other two. The lesions eventually spread elsewhere on the body in two patients. Similar to morphea, which is a well‐known side effect of irradiation, we believe that radiotherapy can induce tissue damage, leading to dermal inflammation ultimately responsible for the emergence of granuloma annulare.

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