Baicalein attenuates sepsis-associated encephalopathy by inhibiting ASK1–JNK and NF-κB pathways

Key Points

• This research aims to explore how baicalein affects sepsis-associated encephalopathy by targeting specific signaling pathways.
• Analyzed the effects of baicalein on sepsis-associated encephalopathy in a laboratory setting.
• Examined the impact on ASK1–JNK and NF-κB signaling pathways.
• Conducted assessments of both anti-inflammatory and neuroprotective effects.
• Baicalein significantly reduced markers of inflammation associated with sepsis.
• The compound inhibited the activation of ASK1–JNK and NF-κB pathways.
• Neuroprotective effects were confirmed, implying potential therapeutic benefits.