What question did this study set out to answer?

This research aims to evaluate the proapoptotic and antiproliferative effects of natural compounds on gynecological cancer cells using in vitro and digital twin methods.

March 12, 2026Ginekologia Polska0 citationsOpen Access

Integrative in vitro and digital twin in silico evaluation of selected natural compounds’ proapoptotic and antiproliferative effects on gynecological cancer cells

RDRadoslaw DzikAcademy of Fine Arts in Katowice AKAnna KleczkaMedical University of Silesia ABAgnieszka BregulaMedical University of Silesia

Key Points

This research aims to evaluate the proapoptotic and antiproliferative effects of natural compounds on gynecological cancer cells using in vitro and digital twin methods.
Conducted in vitro assays to test compounds CA and CAPE
Implemented digital twin simulations to enhance mechanistic analysis
Compared the efficacy of CA and CAPE in anticancer activity
CAPE showed greater anticancer efficacy than CA
Integration of in vitro and digital simulations improved understanding of mechanisms
CAPE is identified as a promising candidate for cancer treatment

Abstract

CA and CAPE both show anticancer activity, with CAPE demonstrating greater efficacy. Integration of in vitro assays with digital twin simulations strengthens mechanistic interpretation and highlights CAPE as a promising anticancer candidate.

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