DLD, upregulated by YY1, fuels glioblastoma multiforme progression via EphA2 phosphorylation to activate PI3K/AKT/mTOR

Key Points

• The research aims to understand how DLD contributes to the progression of glioblastoma multiforme through specific molecular pathways.
• Identified DLD's upregulation by YY1 in glioblastoma multiforme cells
• Investigated the role of EphA2 phosphorylation in the activation of the PI3K/AKT/mTOR pathway
• Assessed the potential of DLD as a biomarker and therapeutic target
• DLD is found to promote glioblastoma multiforme progression as an oncogene
• YY1 significantly increases DLD expression in GBM
• EphA2 phosphorylation is activated by DLD leading to PI3K/AKT/mTOR pathway activation