IL-17A Promotes NETs Formation via the PKCζ-ERK-ROS-PAD4 Pathway in a Mouse Model of Ischemic Stroke.

Key Points

• The study investigates how IL-17A contributes to NETs formation during ischemic stroke and its potential as a therapeutic target.
• Utilized a mouse model of ischemic stroke
• Examined the role of IL-17A in facilitating NETs formation
• Analyzed the PKCζ-ERK-ROS pathway's involvement in the process
• Assessed PAD4 expression levels
• IL-17A was found to significantly upregulate PAD4
• Activation of the PKCζ-ERK-ROS pathway was confirmed
• NETs formation was exacerbated in the presence of IL-17A
• Targeting these pathways may reduce ischemic brain injury