Objectives To determine the level of dysfunctional high‐density lipoprotein (dHDL) with the myeloperoxidase/paraoxonase‐1 (MPO/PON‐1) ratio and its relationship with epicardial adipose tissue thickness (EATT) in patients with ankylosing spondylitis (AS). Methods Total cholesterol, triglyceride, HDL, low‐density lipoprotein, MPO, and PON‐1 levels of 50 AS patients and 50 healthy volunteers were studied. The MPO/PON‐1 ratio was calculated as the dHDL marker. EATT and ejection fraction of patients and the control group were measured by echocardiography. Results There was no difference between the patient and control groups in terms of HDL, LDL, and triglyceride levels ( p > 0.05 for all). A significant difference was detected between the two groups in terms of MPO, PON‐1 levels, MPO/PON‐1 ratio, and EATT ( p < 0.05 for all). While there was a positive correlation between MPO level and MPO/PON‐1 ratio and EATT, a negative correlation was found between PON‐1 level and EATT ( p < 0.05 for all). Conclusions We found that the ratio of MPO/PON‐1, which is considered a biochemical marker of coronary artery disease (CAD), is higher in AS patients. Additionally, we demonstrated a significant relationship between EATT and the MPO/PON‐1 ratio. We showed the relationship with the ratio. We think that the MPO/PON‐1 ratio and EATT may be associated with subclinical cardiovascular risk in patients with AS; however, their potential diagnostic utility requires further longitudinal studies specifically designed to evaluate predictive performance.
Altan et al. (Thu,) studied this question.