This study aims to present and analyze the institutional experience in the diagnosis, treatment, and postoperative outcomes of infantile brain tumors. A retrospective review was conducted of medical records of infants (≤1 year) who underwent initial surgical treatment of supratentorial brain tumors between 2002 and 2024. Indications for tumor resection included mass effect, symptomatic lesions (e.g., increased intracranial pressure (ICP) or focal deficits), or radiologically confirmed tumor progression. Continuous data were summarized as medians or means, and categorical variables as counts and percentages. Survival analyses were performed using the Kaplan–Meier method with log-rank testing, while Cox regression, logistic models, and Fisher’s exact test assessed prognostic and functional associations (p < 0.05, Jamovi v2.6). Our analysis included 34 infants. Signs of ICP were observed in 65% of patients. Tumors were predominantly intraventricular (38%), with choroid plexus tumors being the most common (38%). The median follow-up was 48 months. Gross total resection was achieved in 58% of initial resections, while high-grade histopathology was independently correlated with incomplete tumor removal (p = 0.016). Additionally, high-grade tumors were also associated with poorer prognosis, with a 5-year overall survival of 63% compared to 100% for low-grade tumors. In our institutional experience, infants with supratentorial tumors often presented with late, non-specific symptoms related to increased ICP. Surgical treatment focused on maximal safe resection, although complete removal was not always feasible in a single procedure.
Sordyl et al. (Sun,) studied this question.
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