This research aims to explore the timing of epigenetic age acceleration in children before the onset of type 1 diabetes.
Conducted a longitudinal study with children from the Diabetes Autoimmunity Study in the Young (DAISY) cohort.
Monitored changes in epigenetic age over time.
Assessed autoantibody seroconversion related to type 1 diabetes.
Identified epigenetic age acceleration occurring prior to the seroconversion of islet autoantibodies.
Highlighted possible connections between environmental stressors and the early onset of type 1 diabetes.
Abstract
These results suggest that EAA occurs in children who develop type 1 diabetes prior to IA seroconversion, highlighting the potential role of early environmental stressors in disease pathogenesis.