What question did this study set out to answer?

This study aims to identify risk factors associated with COVID-19 symptom severity in hospitalised patients.

March 13, 2026Open Access

Risk factors for COVID-19 symptom severity across clinical categories among hospitalised patients in Kuala Lumpur, Malaysia: a prospective cohort study

Key Points

This study aims to identify risk factors associated with COVID-19 symptom severity in hospitalised patients.
Prospective cohort design
Analysis of clinical categories of COVID-19 severity
Monitoring of patient factors including age, symptom clusters, and laboratory markers
Higher clinical severity linked to increased ICU admission rates
Age and delta variant infection identified as significant risk factors
Lymphopenia, hyperglycaemia, and elevated pro-inflammatory cytokines noted in higher-risk patients

Abstract

An increasing clinical severity category was strongly associated with ICU admission and mortality. Age, delta infection, specific symptom clusters, lymphopenia, hyperglycaemia and pro-inflammatory cytokines identified higher-risk patients, supporting risk-stratified management and prioritisation for enhanced monitoring.

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