Downregulation of microRNA-1 (miR-1), the most abundant muscle-enriched microRNA, represents a conserved hallmark of skeletal muscle hypertrophy across species. We propose that mechanical overload-induced reduction in miR-1 expression drives metabolic reprogramming critical for hypertrophic adaptation. This review explores emerging evidence establishing miR-1 as a master regulator of metabolism that governs skeletal muscle growth. Summary: microRNA-1 downregulation during mechanical overload enables skeletal muscle hypertrophy through metabolic reprogramming.
Daredia et al. (2026) studied this question.