Neuroprotective and Anti-Inflammatory Strategies for Corneal Nerve Regeneration and Ocular Surface Stability After Corneal Refractive Surgeries: A Systematic Review

Key Points

• The aim is to evaluate neuroprotective and anti-inflammatory strategies for corneal nerve regeneration and ocular surface stability after refractive surgeries.
• Conducted a systematic review of existing literature on corneal nerve regeneration strategies.
• Analyzed evidence from trials focusing on topical cyclosporine and other interventions.
• Assessed the impact on tear film stability post-keratorefractive surgery.
• Topical cyclosporine demonstrated the strongest evidence for enhancing corneal nerve function.
• Reported improvement in long-term tear film stability.
• Limited overall evidence necessitates further large-scale studies.