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March 13, 20260 citations

Enhancing the Diagnostic Performance of Early Lung Cancer by Integrating Multiplex Nucleic Acid Aptamer Detection With Conventional Tumor Markers: A Prospective Observational Study.

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HYHongxia YuanWWWeijun WangZWZhengli Wei

Key Points

  • The study aims to evaluate the effectiveness of combining nucleic acid aptamer detection with conventional tumor marker tests for diagnosing early lung cancer.
  • Conducted a prospective observational study
  • Integrated nucleic acid aptamer detection with conventional tumor markers
  • Evaluated diagnostic performance for early lung cancer
  • Enhanced diagnostic accuracy observed with the combined approach
  • Improved discriminative ability for early lung cancer detection
  • Indicative of a promising optimized strategy for early detection

Abstract

Integrating nucleic acid aptamer detection with conventional tumor marker testing enhances the diagnostic accuracy and discriminative ability for early lung cancer. The incremental value of this combined approach suggests a potential optimized strategy for early lung cancer detection.

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Cite This Study

Yuan et al. (2026) studied this question.

synapsesocial.com/papers/69b3acf302a1e69014ccf170https://doi.org/10.1097/coc.0000000000001316
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Diagnostic Performance of the AptoDetect™-Lung Biomarker for Lung Cancer in a High-Risk Korean Population: A Multicenter Prospective Study2026
  2. 2460P Evaluation of a multiplex circulating tumour DNA panel for detecting lung cancer in a high-risk multicentre cohort2026
  3. 3Advances in Aptamer Diagnostics Targeting Non-Small-Cell Lung Cancer: A Systematic Review2026
  4. 4462P Plasma-based genetic characterization in advanced non-small cell lung cancer: From real-world evidence to prognostic stratification2026
  5. 5Development and validation of a methylation-specific droplet digital PCR multiplex for lung cancer detection2025 · 5 citations