What question did this study set out to answer?

To explore the relationship between colorectal adenoma presence and gut microbiome functions.

March 14, 2026PLoS ONE0 citationsOpen Access

Colorectal adenoma presence is associated with decreased menaquinone pathway functions in the gut microbiome of patients undergoing routine colonoscopy

IVIlona Vilkoite ISIvars Silamiķelis JKJānis Kloviņš

Key Points

To explore the relationship between colorectal adenoma presence and gut microbiome functions.
Assess gut microbiome composition via routine colonoscopy in patients with colorectal adenomas.
Evaluate microbial metabolic functions linked to vitamin K₂, amino acids, and propionate production.
Colorectal adenomas correlated with reduced microbial metabolic functions.
Identified compositional shifts toward a less robust gut microbiome in adenoma patients.
Findings suggest functional microbiome alterations may serve as biomarkers for dysbiosis.

Abstract

The presence of colorectal adenomas was associated with reduced microbial metabolic functions linked to vitamin K₂ biosynthesis, amino acid fermentation, and propionate production, alongside compositional shifts toward a less functionally robust gut microbiome. These findings indicate that early colorectal neoplasia is accompanied by functional microbiome alterations that may serve as markers of adenoma-associated dysbiosis and provide insight into early metabolic changes in the colonic microenvironment.

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