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March 14, 2026JACC Case Reports0 citationsOpen Access

Large PPM Lead–Associated Thrombus in a JAK2-Positive Patient

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DND. NelsonCSCassandra SpanosTRTimothy J. Roberts

Key Points

  • To examine the clinical significance of large intracardiac lead-associated thrombi in patients with JAK2 mutations.
  • Case report of a JAK2-positive patient
  • Assessment of thrombus size and characteristics with imaging
  • Discussion on anticoagulation treatment options
  • Evaluation of treatment decisions based on individual patient factors.
  • Identification of a large intracardiac thrombus in a JAK2-positive individual
  • Emphasis on the importance of individualized treatment plans for anticoagulation
  • Discussion of clinical implications of lead-associated thrombi in patients with CIED.

Abstract

Large intracardiac CIED-related thrombi remain clinically significant but poorly studied. Anticoagulation is the mainstay of treatment, however decisions are highly individualized.

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Cite This Study

Nelson et al. (2026) studied this question.

synapsesocial.com/papers/69b4ba3618185d8a39802eb6https://doi.org/10.1016/j.jaccas.2026.106862
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