Association Between Folate Status and Risk of Cervical Cancer: A Systematic Review, Dose–Response Meta-analysis, and Mendelian Randomization Study

Key Points

• The aim is to examine the association between folate status and the risk of cervical cancer using various analytical methods.
• Conducted a systematic review of existing literature
• Performed a dose–response meta-analysis
• Utilized Mendelian randomization to assess genetic variations related to folate status
• Identified a significant association between low folate status and increased risk of cervical cancer
• Mendelian randomization indicated that genetic factors influencing folate may affect cervical cancer risk