What question did this study set out to answer?

To analyze the patients' window period for disease detection in clinical trials using statistical fitting models.

March 14, 20260 citationsOpen Access

Exponentiated Gamma Distribution on Patients Window Period in Clinical Trials

BBBoahen Eric BoahenGhana Communication Technology University

Key Points

To analyze the patients' window period for disease detection in clinical trials using statistical fitting models.
Conducted at Komfo Anokye Teaching Hospital with 204 patients reporting for stroke treatment.
Data was collected on the time until disease detection post-exposure, utilizing exponential plotting.
Statistical analysis was performed to estimate parameters of exposure times against a common starting window period.
The data fitted better to Gamma Distribution than to Exponential Distribution.
Patients had a guaranteed time frame of several months to disease detection without failure.

Abstract

Patients window period in clinical studies is the time between exposure to a disease and the point when a test can detect the disease. The study was conducted at Komfo Anokye Teaching Hospital where 204 patients were followed after reporting for stroke treatment. For comprehensive analysis and estimation of parameters, individual patient’s different exposure time until the disease detection were allowed to begin at a common starting window period (w). The data was extracted through exponential plotting fitting points and the result revealed that the was not perfectly followed exponential distribution but rather it was fitted to Gamma Distribution. Patients who reported for treatment at Komfo-Anokye Teaching Hospital have a guarantee time of months to months without failure.

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