Lonidamine-1,3,4-oxadiazole derivatives with antiproliferative effects on HCT116 colon cancer cell lines: biological evaluation, ADMET, and computational studies | Synapse
March 14, 2026RSC Advances3 citationsOpen Access
Lonidamine-1,3,4-oxadiazole derivatives with antiproliferative effects on HCT116 colon cancer cell lines: biological evaluation, ADMET, and computational studies
To design and synthesize lonidamine-1,3,4-oxadiazole derivatives and assess their biological activity against colon cancer cells.
Designed and synthesized derivatives using a structure-based approach
Evaluated cytotoxicity on HCT116 colon cancer cell lines
Conducted biological evaluations and ADMET studies
Demonstrated antiproliferative effects of the synthesized compounds
Identified derivatives with significant cytotoxicity against HCT116 cells
Highlighted the potential of these compounds for further development in cancer treatment.
Abstract
Herein, we have employed a structure-based approach, designed and synthesized conjugates of lonidamine-1,3,4-oxadiazole, and evaluated its cytotoxicity profile on a colorectal cancer cell line.