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Trefoil Factor‐3 Is a Hypoxia‐Triggered Pro‐Tumorigenic Factor in Hepatoblastoma | Synapse

March 15, 2026Open Access

Trefoil Factor‐3 Is a Hypoxia‐Triggered Pro‐Tumorigenic Factor in Hepatoblastoma

Key Points

This research examines the role of Trefoil Factor-3 (TFF3) in promoting tumor activity in hepatoblastoma under hypoxic conditions.
Investigated TFF3's role as a hypoxia-inducible factor in hepatoblastoma cells.
Analyzed effects on cell proliferation, survival, and chemoresistance.
Examined the involvement of C-MYC and mTOR pathways.
TFF3 enhances proliferation and survival of hepatoblastoma cells under hypoxia.
Demonstrated increased chemoresistance in the presence of TFF3.
Identified TFF3 as a potential therapeutic target and circulating biomarker.

Abstract

TFF3 is a hypoxia-inducible factor that enhances HB cell proliferation, survival and chemoresistance. Its tumour-promoting activity through C-MYC and mTOR pathways identifies TFF3 as a potential therapeutic target and circulating biomarker in hepatoblastoma.

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Cite This Study

Martínez‐Pérez et al. (Fri,) studied this question.

synapsesocial.com/papers/69b6068883145bc643d1c74c https://doi.org/https://doi.org/10.1111/liv.70592