Lymphadenopathy refers to the enlargement of lymph nodes that can be due to autoimmune disease, and malignancy or microbial infections. The lymph nodes, often referred to as lymph glands, are essential for the bodys ability to combat infections. They function as filters, capturing viruses, bacteria, and other pathogens before they have the chance to infect other regions of the body. Frequently, swollen lymph nodes can be found in the neck, beneath the chin, in the armpits, and in the groin. Lactate dehydrogenase (LDH), β2 Microglobulin, Total bilirubin, direct bilirubin, alanine aminotransferase (ALT), aspartate aminotransferase (AST), Albumin, Creatinine and urea were measured in serum of children with lymphadenopathy to help for diagnosis and monitoring of lymphadenopathy. The results Showed that, there was significant increase in serum LDH level and β2 Microglobulin, ALT, AST in children with lymphadenopathy compared to healthy control children (P value = 0.005), (P value = 0.006), (P value = 0.026), (P value = 0.004) respectively. there was no significant differences in serum level of total. bilirubin, direct bilirubin, Albumin, Creatinine and urea in children with lymphadenopathy compared to healthy control children (P value = 0.322), (P value = 0.098), (P value = 0.694), (P value = 0.837), (P value = 0.850) respectively.
El-Shafey et al. (Tue,) studied this question.