Abstract This short review highlights recent advances in the enantioselective gold-catalyzed cycloisomerization of 1,6-enynes as an efficient strategy for accessing oxa- and aza-bicyclo4.1.0hept-4-enes as well as bicyclo3.1.0 hexane derivatives. Emphasis is placed on the development of chiral gold catalysts and tailored substrate designs that enable high levels of chemo-, regio-, and stereocontrol despite the linear coordination geometry of gold(I). Mechanistic insights, including ligand effects and secondary interactions such as hydrogen bonding, are discussed to rationalize selectivity trends. The review also illustrates how these methodologies have enabled concise syntheses of biologically relevant molecules and hedonic compounds, underscoring the growing maturity and synthetic relevance of asymmetric gold catalysis.
Clisson et al. (Fri,) studied this question.