Long term use of proton pump inhibitors and risk of stomach cancer: population based case-control study in five Nordic countries

Key Points

• To investigate the association between long-term use of proton pump inhibitors and the risk of developing stomach cancer.
• Population-based case-control design
• Data collected from five Nordic countries
• Comparison of long-term proton pump inhibitor users with non-users
• Potential increased risk of stomach cancer associated with long-term proton pump inhibitor use
• Findings indicate higher risk in specific subpopulations
• Results suggest need for careful consideration in prescribing practices