Comparing multi-b-value diffusion models and ROI delineation strategies for prediction of p53 abnormality and microsatellite instability in endometrial cancer

Key Points

• To evaluate the effectiveness of different diffusion models and ROI delineation strategies for predicting p53 abnormalities and microsatellite instability in endometrial cancer.
• Compared multi-b-value diffusion models
• Delineated regions of interest (ROI)
• Assessed diagnostic performance metrics
• MD from a single-slice ROI shows optimal identification of p53 abnormality
• ADC from a whole-tumor ROI exhibits superior sensitivity for MSI prediction
• Operational simplicity and high reproducibility noted for identified approaches