Exploring Key Target Genes of Tong Bian Bai Tou Weng Decoction for Ulcerative Colitis: A Combined Approach of Mendelian Randomization, Network Pharmacology, and Transcriptomics

Key Points

• This research aims to identify key target genes of Tong Bian Bai Tou Weng decoction for ulcerative colitis treatment.
• Combined Mendelian randomization approach
• Network pharmacology analysis
• Transcriptomics assessment
• Identified STAT1, PPARG, and IL1B as significant therapeutic targets for ulcerative colitis.
• Provided a mechanistic framework for understanding ulcerative colitis treatment with herbal decoction.