Shengjiang Xiexin Decoction Mitigates Irinotecan-Triggered Delayed-OnsetDiarrhea by Modulating Short-Chain Fatty Acids and the TLR4-MyD88-JNK/NF-κB Pathway

Key Points

• The central aim is to assess the effectiveness of Shengjiang Xiexin Decoction in reducing diarrhea caused by irinotecan chemotherapy.
• Analyzed the impact of SXD on diarrhea onset triggered by irinotecan.
• Examined the modulation of short-chain fatty acids and the TLR4-MyD88-JNK/NF-κB pathway.
• SXD significantly reduced the incidence of delayed-onset diarrhea.
• Modulation of short-chain fatty acids was observed with SXD treatment.
• The TLR4-MyD88-JNK/NF-κB pathway was positively influenced by SXD.