Testing the performance of polygenic scores for multiple traits to explain cerebral palsy in two independent cohorts

Key Points

• The research aims to evaluate how well polygenic scores can explain the traits associated with cerebral palsy.
• Analyzed polygenic scores for multiple traits
• Utilized two independent cohorts for validation
• Compared genetic associations with cerebral palsy across traits
• Polygenic scores showed varying performance in explaining traits related to cerebral palsy
• Certain traits were more strongly associated with the condition than others
• The findings support the role of genetics in cerebral palsy risk