Unimolecular GLP ‐1/Apelin Hybrid Peptides Cause Prominent Appetite Suppression, as Well as Enhancing Insulin Secretion, Beta‐Cell Survival and Glycaemic Regulation

Key Points

• To explore the therapeutic potential of GLP-1/apelin hybrid molecules for obesity and T2DM management.
• Designed and synthesized GLP-1/apelin hybrid peptides
• Evaluated the effects on appetite and insulin secretion
• Assessed beta-cell survival and glycaemic regulation
• Hybrid peptides caused significant appetite suppression
• Enhanced insulin secretion observed
• Improved beta-cell survival and glycaemic regulation noted