Scalp electroacupuncture targeting trigeminal nerve activation alleviates post‐traumatic stress disorder–induced depression and neuroinflammation in mice

Key Points

• The objective is to investigate the effects of scalp electroacupuncture on depression and neuroinflammation induced by PTSD in a mouse model.
• Utilized a mouse model to simulate PTSD symptoms
• Applied scalp electroacupuncture targeting the trigeminal nerve
• Measured effects on neuroinflammation and depression-related behaviors
• Assessed involvement of the P2X7 receptor pathway and the norepinephrine system
• Observed reduction in neuroinflammation markers in treated mice
• Demonstrated antidepressant effects through behavioral assessments
• Showed changes in the P2X7 receptor activity
• Highlighted improvement in anxiety-like behaviors