The research aims to evaluate serum peripherin as a biomarker for detecting peripheral nerve system damage in hereditary transthyretin amyloidosis.
Multicenter cohort study design
Measurement of serum peripherin levels
Analysis of presymptomatic and symptomatic stages of ATTRv
Elevated serum peripherin levels correlate with damage to the peripheral nervous system (PNS)
Increased levels are detectable even before symptoms appear
Abstract
This study demonstrates that serum peripherin represents a promising biomarker for early detection of PNS damage in ATTRv, with elevated levels detectable even in presymptomatic stages.