Serum peripherin as a disease biomarker in hereditary transthyretin amyloidosis: a multicenter cohort study

Key Points

• The research aims to evaluate serum peripherin as a biomarker for detecting peripheral nerve system damage in hereditary transthyretin amyloidosis.
• Multicenter cohort study design
• Measurement of serum peripherin levels
• Analysis of presymptomatic and symptomatic stages of ATTRv
• Elevated serum peripherin levels correlate with damage to the peripheral nervous system (PNS)
• Increased levels are detectable even before symptoms appear