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March 19, 2026ESMO Open0 citationsOpen Access

240P Molecular drivers and temporal patterns of recurrence after R0 in non-small cell lung cancer: EGFR- and ALK-specific insights from the GECP thoracic tumour registry

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RAR. AguadoMDM.A. Cobo DolsMGM. Domine Gomez

Key Points

  • The study aims to examine how molecular alterations affect recurrence patterns and survival after complete resection in non-small cell lung cancer.
  • Characterized recurrence patterns among patients with EGFR mutations and ALK rearrangements.
  • Analyzed recurrence-free survival (RFS) data from a thoracic tumour registry.
  • Identified temporal patterns of recurrence after R0 resection.
  • Patients with EGFR mutations showed distinct recurrence patterns compared to ALK-rearranged tumors.
  • Recurrence-free survival varied significantly between the two molecular subtypes.
  • Timing of recurrence was influenced by specific molecular alterations.

Abstract

Molecular alterations are an important factor when addressing treatment and may also influence the timing and risk of recurrence after complete (R0) resection in NSCLC. This study aimed to characterise recurrence-free survival (RFS) and recurrence dynamics in patients with EGFR-mutated and ALK-rearranged tumours.

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Cite This Study

Aguado et al. (2026) studied this question.

synapsesocial.com/papers/69bb928c496e729e6297feechttps://doi.org/10.1016/j.esmoop.2026.106548
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