Despite approximately two-thirds of adolescents with PWS entering puberty spontaneously, the majority demonstrated hypogonadism before transitioning to adult care, emphasising the need for ongoing pubertal assessment in this population. Aetiology is predominantly central hypogonadism, but there can also be a component of primary hypogonadism. Longitudinal controlled studies are required to determine optimal detection of hypogonadism and timing of pubertal hormone replacement in PWS.
Nguyen et al. (Mon,) studied this question.